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Background: Narcolepsy is a disabling sleep-wake disorder characterized by the pentad symptoms of excessive daytime sleepiness, sleep paralysis, sleep fragmentation, sleep-related hallucinations, and cataplexy. Taking baclofen for narcolepsy without cataplexy I started on Baclofen at 20mg about 7 months ago and quickly went up to 30mg and have stayed at that dose since. It does not, however, have any significant effect on cataplexy and daytime sleepyness, as Xyrem (sodium gammahydroxybutyrate) does The classic symptoms of narcolepsy include abnormal sleepiness during the day, disturbed sleep at night, hallucinations, sleep paralysis and cataplexy. Select drug class All drug classes vasopressors (1) miscellaneous anxiolytics, sedatives and hypnotics (4) CNS stimulants (20) miscellaneous central nervous system agents (2) decongestants (1) serotonin-norepinephrine reuptake inhibitors (1). The investigators concluded that future studies are warranted,. Twenty-six narcoleptic teenagers with recent onset of narcolepsy-cataplexy sy …. There is no curative therapy for narcolepsy. I quit vaping 6 months ago because I developed a persistent. Unlike narcolepsy type 1, it does not cause a sudden loss of muscle tone Adverse effects associated with the use of baclofen include depression, hallucinations, dizziness, sensory disturbances, and nausea. Our findings suggest that baclofen could be helpful for cataplexy at moderate night-time doses, possibly in older non-adolescent patients and could be a safer and cheaper alternative to GHB. Baclofen use in narcolepsy with cataplexy therefore warrants further investigation. Drugs used to treat Narcolepsy The following list of medications are in some way related to or used in the treatment of this condition. Narcolepsy without cataplexy, or narcolepsy type 2, is a condition that causes excessive daytime sleepiness. While a 2009 study by Huang and Guilleminault3 of 13 narcolepsy-cataplexy patients treated with another GABA-B agonist, baclofen, yielded negative results, a recent report in a mouse model has. Baclofen is a centrally acting GABA-beta agonist that is frequently used in pediatric patients for the treatment of dystonia, rigidity, and spasticity, which are associated with a variety. Narcolepsy is found among people who take Baclofen, especially for people who are female, 50-59 old. Elliott Kyung Lee,1,2 Alan Bruce Douglass1,2 1Department of Psychiatry, Faculty of Medicine, Institute of Mental Health Research, University of Ottawa,. Disclosure The authors report no conflicts of interest in this work (N1) Narcolepsy w/ Cataplexy I tried baclofen a few times and it made me a zombie the next day, even at low doses… not even my stims could shake off the zombieness. A 2014 mice study found that giving R-baclofen (R-BAC) 2. I felt like a normal person some days and the improvement felt much more natural than stimulants. 8 milligram per kilogram twice nightly — the same dosing regimen given to people with narcolepsy — suppressed cataplexy to a greater extent. The phase IV clinical study analyzes which people take Baclofen and have Narcolepsy. Ago Narcolepsy & Cataplexy Not a good idea if you have an apnea or respiratory matter, as it is a respiratory depressant, which can be a danger. Treatment is therefore symptom directed Narcolepsy is found among people who take Baclofen, especially for people who are female, 50-59 old. The intensity of the symptoms can be very different from one patient to another, and some symptoms (e. It was the best Ive felt since being diagnosed with narcolepsy. Treatment is therefore symptom directed Treatment goals of narcolepsy therapy are directed at specific relief of symptoms, including excessive daytime sleepiness, sleep fragmentation, and cataplexy. Cataplexy) may be completely absent (8). Excessive sleepiness during daytime.
